Chem 128. Lec. 05. Intro to Chemical Biology. Non-Covalent Interactions, DNA (English)
UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 05. Introduction to Chemical Biology --Non-Covalent Interactions, DNA.
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.
Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/openchem
Recorded on January 22, 2013.
0:10:56 - Our Story Thus Far (Thursday)
0:10:58 - Charge-Charge Interactions
0:11:11 - The Lennard-Jones Potential
0:14:28 - Rouges Gallery of Non-Covalent Interactions
0:21:44 - Comparing Energetics
0:25:06 - All Biology Involves Water
0:26:40 - Water next to Hydrophobic Surfaces
0:28:36 - Receptor-Ligand Interactions
0:33:01 - Biooligomers on Earth: Modularity
0:33:48 - Numerical Amplification in Biosynthesis
0:34:35 - Form Follows Function in Biology
0:39:51 - Non-Covalent Bonding Summary
0:43:31 - Structure of DNA: Double Helix
0:44:57 - Structure of DNA: Double Helix, Slide 2
0:46:24 - DNA Structure Sets Up Replication
0:47:42 - Early Attempts at Deciphering the Structure of DNA
0:48:31 - DNA Inside the Cell is Tightly Organized
0:49:02 - The DNA Bases
0:51:39 - DNA Bases: Not That Basic
0:52:40 - The Missing 2-OH of DNA Confers Stability
0:54:24 - White Board Example
0:59:25 - The DNA Bases are Subject to Modification
1:01:39 - Watson-Crick Base Pairs form U-Shape
1:02:35 - The Edges of the DNA Bases Provide a Basis for Molecular Recognition
1:04:02 - Transcription Factors Recognize Specific DNA Sequences
1:04:59 - Forces Holding Together DNA Double Helix
1:06:28 - Base Pairing Requires Hydrogen Bond Donors and Acceptors
1:08:36 - Unnatural Bases Can Shift Recognition
1:10:27 - Chemical Biologists Synthesized DNA With Unnatural Bases
1:12:32 - Stabilization of DNA by Pi-Stacking
1:12:52 - Alternative Base Pairing Also Possible
1:14:13 - DNA Intercalation: Untwisting of DNA
1:14:56 - Examples of DNA Intercalators
1:17:03 - More DNA Intercalators
Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.
- Gregory Alan Weiss
Chem 128. Intro to Chemical Biology. Lecture 5: Non-Covalent Interactions, DNA by Gregory Weiss is licensed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.