Chem 128. Lec. 03. Intro to Chemical Biology. Reactivity and Arrow Pushing (English)
UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 03. Introduction to Chemical Biology -- Reactivity and Arrow Pushing
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.
Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/openchem
Recorded on January 3, 2013.
0:05:29 - Our Story to Date on Tuesday...
0:07:01 - What is Life?
0:09:07 - Arrows Depict the Overlap of Molecular Orbitals
0:14:33 - The Clash of Two Possible Wills
0:17:16 - Arrows Depict the Overlap of Molecular Orbitals
0:19:57 - The Three Components of Orbital Overlap
0:21:35 - Arrows Depict the Overlap of Molecular Orbitals (revisited)
0:21:53 - The Three Components of Orbital Overlap (revisited)
0:24:27 - Charge-Charge or Coulombic Effects
0:26:31 - Molecular Orbital Theory Explains the Otherwise Unexplained
0:28:05 - Combining Atomic Orbitals to Make Hybrid Atomic Orbitals
0:34:17 - Combining Hybrid Atomic Orbitals to Make Molecular Orbitals
0:39:56 - Highest Occupied Molecular Orbital
0:41:57 - Lowest Unoccupied Molecular Orbitals (LUMOs)
0:44:08 - Anatomy of an Arrow
0:46:38 - 3 Rules for Mechanistic Arrow-Pushing
0:50:34 - The Rules for Arrow Pushing in Action
0:57:02 - Draw Correct Lewis Structures
0:58:23 - Arrows Start With Bonds or Lone Bairs
1:00:08 - Arrows End on Atoms or Bonds
1:01:27 - H Is Always Attached to Something
1:04:48 - Hydrogen Bonds
1:07:08 - Do Not Use Curved Arrows for Hydrogen Bonds
1:08:58 - Proton Transfers To and From Heteroatoms are Very Fast
1:09:33 - Proton Transfers Require Linear Geometries
Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.