Chem 128. Lec. 07. Intro to Chemical Biology. DNA, RNA, and Cancer (English)


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UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 07. Introduction to Chemical Biology -- DNA, RNA, and Cancer
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.


License: Creative Commons BY-NC-SA
Terms of Use: http://ocw.uci.edu/info.
More courses at http://ocw.uci.edu


Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/openchem


Recorded January 29, 2013.


Index of Topics:
Announcements
0:00:09 - Week 3 Overview
0:01:28 - Office Hours
0:02:51 - Midterm 1 Info
0:06:24 - Announcements

Lecture
0:06:40 - Our Story Thus Far
0:09:48 - Cutting and Pasting DNA
0:12:22 - Restriction Enzymes Cut DNA Specifically
0:15:00 - "Sticky Ends" Left Over from Restriction Enzymes for Pasting in New DNA
0:16:29 - Cutting and Pasting DNA
0:18:42 - Protein Modification by PCR
0:23:15 - UV from Sunlight Cross-Links Thymines
0:25:09 - E. Coli Photolyase
0:26:36 - Protecting Your Cells By Sun Screen
0:28:39 - Psoralens: The Scourge of Margaritaville
0:30:58 - Psoralen Cross-Linked DNA
0:32:16 - Margarita Photodermatitis (image)
0:33:06 - Margarita Photodermatitis
0:33:24 - Cells Must Advance or Die
0:34:57 - DNA as a Big Nucleophile
0:38:26 - Case Study: Omaha, Nebraska-Sept. 10, 1978
0:39:51 - N-nitrosoamines = Potent DNA Alkylating Agents
0:41:13 - The First Human Trials of N,N-Dimethylnitorsoamine
0:42:40 - Bringing Home the Bacon
0:43:37 - Why Bacon's (Mostly) Ok
0:45:00 - Known Carcinogens
0:47:44 - Paradox: Cause and Cure??
0:50:42 - Excision Repair in Humans
0:52:34 - Monofunctional Alkylating Agents: Often Readily Repairable
0:54:23 - Bifunctional Cross-Linking Agent
0:54:58 - Caution! Bifunctional DNA Alkylators
0:55:47 - Excision Repair In Humans
0:56:46 - Missing Or Deficient DNA Repair Proteins
0:57:25 - Hundreds of Mutations Required to Cause Cancer
1:00:39 - The p53 Tumor Suppressor Protein
1:02:05 - Mutations to p53 are Bad News
1:02:52 - p53 Suppressors Tumors
1:03:57 - Sir Percival Pott
1:05:19 - Testicular Cancer
1:06:13 - Testicular Cancer, Slide 2
1:06:56 - P450 Substrates as Potent DNA Alkylators
1:08:24 - Benzopyrene: Pro-Epoxide DNA Alkylators
1:10:18 - Toxins from Molds Growing on Grains
1:11:36 - Nitrogen and Sulfur Mustards
1:13:35 - The Re-Evaluation of RNA's Importance
1:14:41 - What Levene Got Right
1:15:07 - The Re-Evaluation of RNA's Importance
1:15:53 - RNA: Soldier, Sailor, Tinker, Spy


Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine),  http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.


Author:
Gregory Alan Weiss
Title:
Professor
Department:
Chemistry
Creative Commons License
Chem 128. Intro to Chemical Biology. Lecture 7: DNA, RNA, and Cancer by Gregory Weiss is licensed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.
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