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Chem 128. Lec. 10. Intro to Chemical Biology. Proteins and Amino Acid Conformations (English)


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UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 10. Introduction to Chemical Biology -- Proteins and Amino Acid Conformations -- Part 1
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.


License: Creative Commons BY-NC-SA
Terms of Use: http://ocw.uci.edu/info.
More courses at http://ocw.uci.edu


Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/openchem


Recorded February 12, 2013.


Index of Topics:
Announcements
0:00:08 - Week 6 Overview
0:01:07 - Announcements
0:02:42 - Office Hours
0:03:54 - Careers in Chemical Biology and Health (white board)

Lecture
0:19:40 - Our Story Thus Far
0:22:14 - Proteins: Of Primary Importance
0:23:33 - Must Memorize: 20 aa's, Structures and Abbreviations
0:24:50 - Must Memorize, Slide 2
0:26:31 - Refer to Amino Acids
0:27:24 - Goal: Understand Forces Behind Protein Structure
0:28:38 - Peptides and Protein are Directional
0:32:39 - Useful to Know: pKa Values
0:35:14 - Amino Acid Sidechains Dictate Protein Folding and Protein-Protein Interactions
0:37:09 - Amino Acid Sidechains, Slide 2
0:40:09 - A Close Look at a Protein-Protein Interface
0:42:05 - Peptides Can Make Effective Drugs
0:45:20 - Peptides Can Be the Lead Compounds for Drug Discovery
0:49:29 - Chemical Synthesis of Peptides and Proteins
0:54:41 - Synthesizing Longer Proteins with Native Chemical Ligation
0:59:51 - Protein Splicing to Remove Inteins
1:01:18 - Protein Splicing to Remove Inteins, Slide 2
1:04:31 - Protein Structure: The Sum of Lots of Little Forces
1:06:30 - Geometry of the Hydrogen Bond
1:07:46 - H-Bonds in Proteins
1:09:50 - H-Bonds in a-Helices
1:15:10 - a-Helices Form a Dipole
1:18:27 - a-Helices Form a Dipole, Slide 2


Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine),  http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.


Author:
Gregory Alan Weiss
Title:
Professor
Department:
Chemistry
Creative Commons License
Chem 128: Intro to Chemical Biology. Lecture 10: Proteins and Amino Acid Conformations by Gregory Weiss is licensed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.
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