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Chem 128. Lec. 14. Intro to Chemical Biology. Glycobiology (English)


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UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 14. Introduction to Chemical Biology -- Glycobiology
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.


License: Creative Commons BY-NC-SA
Terms of Use: http://ocw.uci.edu/info.
More courses at http://ocw.uci.edu


Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/openchem


Recorded February 22. 2013.


Index of Topics:
Announcements
0:00:23 - Week 8 Overview
0:01:29 - Announcements

Lecture
0:02:04 - Our Story to Date
0:06:10 - Serine Based Proteases
0:09:07 - Serine Proteases
0:10:34 - Zinc Proteases
0:10:44 - Protein Based Inhibition of Proteases
0:13:10 - Covalent or Mechanism-Based Protease Inhibitors
0:15:02 - Inhibition of Serine Esterases
0:17:07 - Enzymes Use Co-Factors (vitamins)
0:18:02 - Niacin (Vitamin B3) Provides a Reactive Hydride
0:21:31 - The Origins of Stereospecificity in Alcohol Dehydrogenase
0:24:09 - Pyridoxal Phosphate (Vitamin 86)
0:26:27 - PLP as a Co-Factor for Decarboxylation
0:27:29 - PLP-Catalyzed Transamination
0:29:29 - Protein Engineering
0:31:04 - Reverse Engineering Protein Function
0:32:37 - Human Growth Hormone as a Testbed for Protein Engineering
0:32:45 - A Closer Look at the hGH Binding Interface
0:34:12 - Subtilisin as a Testbed for Protein Engineering
0:36:16 - Most Mutations Make the Protein Less Functional
0:38:17 - Carbohydrates
0:40:04 - Only 9 Carbohydrate Building Blocks are Found in Humans
0:40:58 - Carbohydrate Nomenclature
0:42:53 - Anomers of Carbohydrates
0:44:20 - The Anomeric Effect Offers Counterintuitive Stabilization of Carbohydrate Conformations
0:44:30 - Hemiacetal Reactivity and Formation
0:46:33 - Glucopyranose is the Most Noteable Ring Configuration
0:47:51 - Oligosaccharhides of the TB Coat
0:49:40 - Oligosaccharides Form Complex Structures
0:51:29 - Oxocarbenium Ions as a Key Intermediate in Hydrolysis of Glycosidic Bonds
0:53:19 - Mechanisms of Enzymatic Hydrolysis
0:54:58 - Commonalities in Glycosylhydrolase Mechanisms
0:55:35 - Glycosylhydrolase Use Judicious Protonation
0:56:03 - Neuraminidase: Key Enzyme in Influenza Release from Surface of the Cell
0:57:32 - Neuraminidase Inhibitors
1:01:06 - Oligosaccharides
1:02:14 - Biosynthesis of Oligosaccharides
1:03:39 - Mechanism of Glycosyl Transferases
1:04:22 - Polysaccharides
1:06:15 - Chitin: Polymer of N-acetylglucosamine
1:08:04 - Hyaluronan: Oligosaccharides in Joints
1:09:57 - Glycosylated Proteins


Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine),  http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.


Author:
Gregory Alan Weiss
Title:
Professor
Department:
Chemistry
Creative Commons License
Chem 128. Intro to Chemical Biology. Lecture 14: Glycobiology by Gregory Weiss is licensed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.
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