Chem 128. Lec. 15. Intro to Chemical Biology. Glycobiology & Polyketides (English)


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UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 15. Introduction to Chemical Biology -- Glycobiology & Polyketides
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.


License: Creative Commons BY-NC-SA
Terms of Use: http://ocw.uci.edu/info.
More courses at http://ocw.uci.edu


Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/openchem


Recorded March 5, 2013.


Index of Topics:
00:19 - Our Story to Date...
03:13 - Our Story to Date, Slide 2
03:15 - Glycosylated Proteins
04:35 - O-Linked Glycoproteins
07:25 - Extending Oligosaccharides One Monomer at a Time
08:26 - More Knee Joint Oligosaccharides
10:25 - Snot and Mucus: Anionic Polysaccharides
13:21 - N-Linked Glycosides: Added as Complex Oligosaccharides
15:51 - Mechanism for Glycosyl Transfer
20:05 - N-Linked Glycosides Heavily Trimmed
22:56 - What is the Function of Glycosylation?
24:10 - Glycosylation Can Play a Key Role in Anitbody Recognition
25:37 - Cell Culture Production of Proteins
27:54 - Glucoronidation Used to Designate Small Molecules for Excretion
29:49 - Glucose Homeostasis
31:39 - Non-Enzymatic Glycosylation
32:12 - Non-Enzymatic Glycosylation Causes Protein Cross-Linking
35:29 - Sweetners: Taste Good for the Calories
36:33 - Aspartame: Dipeptide Sweetner
37:44 - Other Sweetners
39:24 - Aspartame: Dipeptide Sweetener (revisited)
40:30 - The Central Dogma of Modern Biology
41:00 - Terpenes and Polyketides
41:55 - Polyketides: Natural Products Synthesized by Stepwise Aldol Reactions
43:22 - Polyketides are built by the Claisen Reaction
45:09 - Nature Prefers Thioesters for the Claisen
46:46 - Claisen Reaction in Biology
48:06 - Rapid Exchange of Thioesters
49:28 - Fatty Acid Synthesis by Polyketide
50:07 - Omega Fatty Acids: Crucial for Brain Chemistry
51:24 - Fatty Acid Synthesis by Polyketide
51:54 - Omega Fatty Acids: Crucial for Brain Chemistry (revisited)
53:12 - Fatty Acid Synthase: Paradigm for a Polyketide Synthesis Machine
54:37 - Step 1: Load Thiol onto Acyl Carrier Protein (ACP)
55:30 - Transacylation as a Facile Reaction for Loading Polyketide Subunits
56:06 - Ketosynthases Catalyze a Decarboxylative Claisen Condensation
57:06 - Ketoreductase to Convert Carbonyl to Alcohol Functionality
57:42 - Elimination of the Alcohol to Provide an Olefin
58:05 - Enoyl Reductases to Reduce C=C
58:13 - Last Step: Release from PKS by Thioesterase
58:31 - Fatty Acid Synthase: Paradigm for a Polyketide Synthesis Machine


Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine),  http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.


Author:
Gregory Alan Weiss
Title:
Professor
Department:
Chemistry
Creative Commons License
Chem 128. Intro to Chemical Biology. Lecture 15: Glycobiology & Polyketides by Gregory Weiss is licensed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.
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