Chem 128. Lec. 16. Intro to Chemical Biology. Glycobiology & Polyketides, Part 2 (English)


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UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 16. Introduction to Chemical Biology -- Glycobiology & Polyketides -- Part 2
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.


License: Creative Commons BY-NC-SA
Terms of Use: http://ocw.uci.edu/info.
More courses at http://ocw.uci.edu


Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/openchem


Recorded March 5, 2013.


Index of Topics:
0:00:33 - Our Story to Date
0:08:45 - Fatty Acid Synthase: Paradigm for a Polyketide Synthesis Machine
0:09:06 - Ketosynthases Catalyze a Decarboxylative Claisen Condensation
0:09:30 - Last Step- Release from PKS by Thioesterase
0:10:58 - Plasma Membrane = Lipid Barrier
0:12:07 - Plasma Membrane = Lipid Barrier, Slide 2
0:13:44 - Hydrolysis of Lipids in Cell Signaling
0:15:26 - Prostaglandin Signaling to Coordinate Cell Response
0:16:15 - Leukotrienes Mediate Inflammatory Response
0:19:09 - Shutting Down the Prostaglandin Pathway at its Start
0:19:58 - Leukotrienes Mediate Inflammatory Response
0:20:05 - Shutting Down the Prostaglandin Pathway at its Start (revisited)
0:23:39 - Converting Fats into Soaps
0:25:54 - Diversifying Products from Polyketide Synthases
0:27:36 - Aromatic Natural Products Sythesized from Polyketides
0:29:31 - Complexity in Polyketide Natural Products
0:33:42 - Polyketides are Assembled by Assembly Line-Like Polyketide Synthases
0:37:52 - The PKS Assembly Line is Doughnut Shaped
0:39:54 - Fatty Acid Synthase (FAS) Has a Circular Assembly Line
0:40:56 - Comparing FAS and Erythronolide PKS
0:44:18 - Terpenes: Built from Isoprene (5C) Units
0:46:27 - Terpenes in Biology and Pharmaceuticals
0:49:00 - Terpene Synthases as Factories for Complex Organic Synthesis
0:50:01 - More Complex Terpenes
0:50:13 - Origins of the Head-To-Tail Rule
0:52:04 - Reaction Mechanisms for Terpene Sythesis
0:56:18 - Inhibition of Cholesterol Synthesis
0:57:26 - Connecting Isoprene Units
0:57:48 - Cyclization of Straight-Chain Precursors by Enzymes
1:00:13 - Terpene Synthases Direct Carbocation Cascades--in Water (!)
1:00:37 - Cyclization of Straigh-Chain Precursors by Enzymes


Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine),  http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.


Author:
Gregory Alan Weiss
Title:
Professor
Department:
Chemistry
Creative Commons License
Chem 128. Intro to Chemical Biology. Lecture 16: Glycobiology & Polyketides, Part 2 by Gregory Weiss is licensed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.
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