Chem 128. Lec. 17. Intro to Chemical Biology. Terpenes and Cell Signaling, Part 1 (English)


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UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 17. Introduction to Chemical Biology -- Terpenes and Cell Signaling -- Part 1
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.


License: Creative Commons BY-NC-SA
Terms of Use: http://ocw.uci.edu/info.
More courses at http://ocw.uci.edu


Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/openchem


Recorded March 12, 2013.


Index of Topics:
Announcements
0:00:21 - Week 10 Overview
0:00:41 - Announcements
0:05:42 - Office Hours

Lecture
0:06:34 - Our Story to Date...
0:08:55 - Biogenic head-To-Tail Synthesis of Terpenes
0:10:29 - Mechanism for Head-To-Tail C-C Bond Formation
0:13:25 - Some Common Linear Terpenes
0:14:41 - Protein Prenylation: Localizes Protein to the Membrane
0:18:03 - Bisphosphonates: Anti-Osteoporosis Drugs
0:20:27 - The Rich Structural Diversity of Terpenes
0:21:35 - Cyclization Cascades in Biosynthesis
0:23:29 - Biosynthesis of Lanosterol
0:26:19 - Humans Cannot Synthesize Retinoids
0:28:29 - Dialing-In the Pink Color of Salmon
0:30:15 - Non-Human Terpenes in Plants and Microorganisms
0:33:01 - Reaction to Dye Brunette Hair Blonde Before the Invention of Hydrogen Peroxide
0:34:51 - Cyclization of Isoprene Oligomers
0:39:51 - Control Over the Central Dogma
0:42:22 - Ancient Small Molecules with Bioactivity
0:44:53 - Cell Signaling by Small Molecules
0:46:08 - Arrows in Chemistry and Biology
0:49:11 - Cell Signaling Scenarios
0:51:24 - Spilling their Guts
0:52:28 - Two Classes of Cell Signaling
0:53:11 - Cell Signaling Involves 7 (seven) Possible Pathways
0:54:50 - The 7 Signaling Pathways
0:56:16 - Genetics to Dissect Complex Biology
0:58:21 - Forward Chemical Genetics
1:01:06 - Small Molecules Offer Control Over Otherwise Unavailable Phenotypes
1:02:16 - High Thoughtput Small Molecule Screening
1:07:48 - Nuclear Hormone Receptors
1:09:48 - Estrogen Signaling
1:11:46 - Retinoic Acid Signaling
1:13:16 - Structure of a Nuclear Receptor Bound to DNA
1:15:10 - Steroids Make Highly Potent Pharmaceuticals
1:16:57 - Non-Steroidal Ligands to Nuclear Receptors
1:18:14 - In Vivo Biosynthesis of Calcitriol
1:19:23 - Restoring Biological Function of a Mutant Vitamin D Receptor


Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine),  http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.


Author:
Gregory Alan Weiss
Title:
Professor
Department:
Chemistry
Creative Commons License
Chem 128. Into to Chemical Biology. Lecture 17: Terpenes and Cell Signaling, Part 1 by Gregory Weiss is licensed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.
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