Chem 128. Lec. 18. Intro to Chemical Biology. Terpenes and Cell Signaling, Part 2 (English)


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UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 18. Introduction to Chemical Biology -- Terpenes and Cell Signaling -- Part 2
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.


License: Creative Commons BY-NC-SA
Terms of Use: http://ocw.uci.edu/info.
More courses at http://ocw.uci.edu


Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/collections/open_chemistry.html


Recorded March 14, 2013.


Index of Topics:
Announcements
0:00:14 - Week 10 Overview
0:00:23 -Announcements
0:02:38 - Office Hours

Lecture:
0:03:13 - Our Story to Date on Thursday...
0:07:19 - The 7 Signaling Pathways
0:09:41 - Control Over Cell Differentiation Through Cytokines
0:11:19 - Excess Growth Hormone Causes Acromegaly
0:11:56 - Control Over Cell Differentiation (revisited)
0:12:04 - Erythropoietin Signals Through the Jak-STAT Pathway
0:14:28 - Erythropoietin Signals Through the Jak-STAT Pathway, Slide 2
0:15:16 - Erythropoietin Signals Through the Jak-STAT Pathway, Slide 3
0:16:03 - Chemical Control Over Cell Signaling Through Dimerization
0:19:25 - Non-Specific Dimerization by Covalent Cross-Linking
0:22:25 - Modification of Proteins for Better Properties
0:25:57 - Growth Factor Signaling Through Cell Surface Kinases
0:27:12 - Receptor Tyrosine Kinases: Growth Factor Signaling
0:28:59 - Human Growth Hormone (hGH)
0:29:52 - Small Molecule Inhibition of RTKs
0:33:19 - Sequential Phosphorylation
0:34:22 - MAP Kinase Signaling
0:35:51 - Already Discussed: SH3 Domain Binding to a Polyproline Helix
0:36:00 - Peptide Binding Domains
0:36:35 - MAP Kinase Signaling (revisited)
0:38:32 - Small Molecules in Cell Signaling
0:41:23 - Key Players: Heparan Sulfate and CA2+
0:42:28 - 4. G Protein-Coupled Receptors
0:44:19 - Turning On and Off Signals from Binding
0:45:46 - Turning On and Off Signals from Binding, Slide 2
0:46:22 - GPCR's Signal Through a G Protein
0:46:42 - Turning On and Off Signals from Binding, Slide 2 (revisited)
0:53:07 - Much Larger Dynamic Range
0:54:02 - GPCR Signaling
0:55:35 - Smell and Taste Signaling through GPCRs
0:56:43 - Small and Taste Signaling through GPCRs, Slide 2
0:58:15 - Vision Through Cis-Trans Olefin Isomerization
1:00:11 - Vision Through Cis-Trans Olefin Isomerization, Slide 2
1:01:35 - 5. Ion Channel Signaling
1:02:41 - Control over the Ca2+ Activated K+ Channel
1:03:31 - Trimeric Death Receptors
1:03:59 - Trimeric Death Receptor Signaling
1:04:38 - Signaling By Diffusible Gas Molecules
1:06:58 - NO Causes Relaxation of Smooth Muscle in Blood Vessles
1:07:36 - NO Causes Relaxation of Smooth Muscle in Blood Vessels,Slide 2
1:08:38 - Chemical Biology: Understanding Biology at the Level of Atoms and Bonds
1:09:25 - Chemical Biology: Who Are We?
1:09:58 - Chemical Biology: Where Did We Come From?
1:10:22 - Chemical Biology: Where Are We Going?
1:11:05 - Chemical Biology: Impacting Society--Join Us At The Frontier


Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine),  http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.


Author:
Gregory Alan Weiss
Title:
Professor
Department:
Chemistry
Creative Commons License
Intro to Chemical Biology 128. Lecture 18. Terpenes and Cell Signaling, Part 2 by Gregory Weiss is licensed under a Creative Commons Attribution-ShareAlike 3.0 Unported License.
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