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UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 11. Introduction to Chemical Biology -- Proteins and Amino Acid Conformations -- Part 2
View the complete course: ../courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.

License: Creative Commons BY-NC-SA
Terms of Use: ../info.
More courses at http://ocw.uci.edu

Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: ../openchem

Recorded February 14, 2013.

Index of Topics:
Announcements
0:00:06 - Week 6 Overview
0:00:30 - Announcements
0:01:41 - Office Hours
0:02:49 - Proposal Abstract (white board)

Lecture
0:28:13 - Our Story Thus Far on Thursday
0:30:53 - a-Helices Form a Dipole
0:31:09 - B-Sheets Come In Two Flavors
0:32:54 - Forming B-Sheets Into Barrels
0:33:58 - B-Sheets Come In Two Flavors, Slide 2
0:34:39 - Secondary Structure- Backbone Conformations
0:35:32 - Sidechains in B-Sheets Stick Out Perpendicular to the Sheet
0:36:53 - Turns Have Minimal H-Bonds
0:40:26 - Turn Structures
0:40:59 - Can (modestly) Predict Secondary Structure Based on Amino Acid
0:44:40 - Conformational Analysis for the Cognoscente (white board)
0:58:07 - Amino Acids Examples (white board)
1:05:01 - Conformations to Watch For
1:08:19 - Conformations to Watch For, Slide 2
1:09:38 - Allylic Strain Dominates the Protein Backbone
1:11:19 - Allylic Strain Explains Dominance of 2 Types of Protein Secondary Structure
1:13:10 - Disulfide Bonds In Proteins
1:14:32 - Formation of Disulfide Bonds in Proteins
1:14:49 - Glutathione as an Intracellular Thiol Buffer
1:15:07 - Facile Disulfide Exchange Happens Constantly
1:15:34 - Protein Structure
1:15:57 - Protein Organization Hierarchy
1:17:33 - Most Common Protein Structures
1:17:50 - All a-Helical Proteins
1:17:53 - Zn Fingers as Very Common a-Helical Proteins

Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine),  ../courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.